Nanoscale Drug Delivery System for Diabetic Wound Treatment

Diabetes mellitus makes plenty of catastrophes to certain population. DFU as one of the most severe complications also makes negative ramifications, resulting in numerous amputations and even deaths, which drives an imperative demand of treating diabetic wound though diabetic wounds heal toughly, due to the internal and external wound environment. As so far, some pathways to cure diabetic wound have already formed, but diverse problems are produced under the conventional tactics like low efficiency of the drugs, trauma and even antibiotics resistances. Hince, nanoscale drug delivery systems (NDDSs) tackle the shortcomings from original methods and spark a novel pathway in diabetic wound healing, which load a variety of functional compositions in order to achieve better efficacy of the diabetic wound agents, owing to the strengths of NDDSs: the drugs can be sustainably released, protected from degradation and targeting delivery and so on. Recently, different substances are encapsuled by distinct materials of nanocarriers including liposomes, polymeric NPs, inorganic NPs, lipid NPs, nanofibers and nanohydrogels. This review not only summarizes the distinct categories of nanoparticles used in diabetic wound treatments but also highlights the outstanding advancements of NDDSs which play a vital role in healing diabetic wound.