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October 15, 2025International Journal of Cell and Biomedical ScienceOpen Access

Comparison of Animal Serum-Free Media Culture for cGMP-Compliant Mesenchymal Stem Cell Expansion

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Authors

RIRisky Chandra Satria IrawanNZNibras ZakiyahBABramassetyo Aji

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Overview

This analysis compares serum-free media for culturing mesenchymal stem cells, revealing implications for pharmaceutical use.

Key Points

  • HPL-supplemented media significantly enhanced cell proliferation by eight times at day zero, indicating strong growth potential.
  • Cytokine evaluations showed higher anti-inflammatory protein levels in HPL-cultured umbilical cord-derived MSCs, suggesting improved biochemical properties.
  • Flow cytometry confirmed over 95% expression of UC-MSC surface markers, ensuring cell identity in serum-free cultures.
  • Morphological assessment revealed UC-MSCs maintained normal characteristics when cultured in serum-free media, validating this alternative method.

Cite This Study

Irawan et al. (2025) studied this question.

synapsesocial.com/papers/68f02c7d616531447b5f93d0https://doi.org/10.59278/cbs.v4i11.74
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