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October 15, 2025International Journal of Cell and Biomedical ScienceOpen Access

Surface Marker Expression and Morphological Alterations in Umbilical Cord-Derived MSCs Over Passages 4 to 9: A Flow Cytometry and Microscopic Analysis

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Authors

SPSalindri PrawitasariDADian Respati AyuRIRisky Chandra Satria Irawan

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Overview

Analysis using flow cytometry shows surface marker retention in UC-MSCs, suggesting implications for regenerative medicine.

Key Points

  • UC-MSCs retained high expression levels of key surface markers across all passages, indicating their potential for therapeutic applications.
  • Flow cytometry demonstrated a decline in surface marker expression in later passages, which may affect their efficacy in regenerative medicine.
  • Morphological assessments revealed a shift from spindle-shaped to enlarged, flattened cells, highlighting signs of senescence in higher passages.
  • The findings underscore the importance of carefully selecting passage numbers for optimizing UC-MSC culture protocols for clinical use.

Cite This Study

Prawitasari et al. (2025) studied this question.

synapsesocial.com/papers/68f02c7d616531447b5f93e7https://doi.org/10.59278/cbs.v3i9.51
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