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October 16, 2025Open Access

NAD metabolism plays multiple roles in influenza A virus replication in a novel ex vivo model of mouse lung infection.

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Authors

FJFlorentine JacolinAAAnne Aublin‐GexMVManon Vellet

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Overview

Research demonstrates NAD metabolism's involvement in Influenza A virus replication, highlighting NAMPT and PARP as potential antiviral targets.

Key Points

  • NAD metabolism is essential for influenza A virus replication and particle production, suggesting a therapeutic target.
  • Inhibition of NAMPT decreases NAD+ levels, while PARPs, which consume NAD+, are upregulated during IAV infection.
  • Untargeted metabolomic profiling revealed significant metabolic alterations in murine lung cultures infected with IAV.
  • Pharmacological inhibition of PARP mono-ART activity reduced IAV infection, indicating its role as an antiviral target.

Cite This Study

Jacolin et al. (2025) studied this question.

synapsesocial.com/papers/68f04918e559138a1a06d3b8https://doi.org/10.1101/2025.10.14.682270
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