Immunohistochemical and histopathological characteristics of adenomas and adenocarcinomas of Meibomian glands in dogs

This study aimed to provide a comprehensive histopathological and immunohistochemical analysis of Meibomian adenomas and adenocarcinomas. A total of 80 tumours were included in the study: 33 adenomas and 47 Meibomian adenocarcinomas. Ki-67, cytokeratin-7 and von Willebrand factor antibodies were used for the immunohistochemical staining. . Detailed characteristics of inflammatory infiltration depending on tumor type and damage to surrounding tissue by tumour cells are presented. A close correlation was found between the structure and intensity of blood vessel proliferation and the level of factor VIII expression. The detailed histopathological analysis presented, combined with the results of immunohistochemical studies, now allows for better treatment planning and prognosis assessment for patients.