Separating the multi dots of retinal active bleeding with discovisc from infusion solution to rapidly restore visibility in severe proliferative diabetic retinopathy surgery

Abstract Purpose To introduce a novel technique for restoring the refractive media transparency in severe proliferative diabetic retinopathy (PDR) surgery by injecting dispersive ophthalmic viscoelastic device (OVD; DisCoVisc) onto the retinal surface to separate the multi dots of active bleeding from infusion solution. Methods DisCoVisc was injected onto the retinal surface to control retinal bleeding diffusion in 12 eyes of 11 patients with severe PDR. The main outcome measures were intraoperative and postoperative vitreous hemorrhage complications. Follow-ups were performed at 1 day, and the last follow-up (ranging from 1 to 6 months) after surgery. Intraocular pressure (IOP) and best-corrected visual acuity (BCVA) measurements were performed preoperatively and at last follow-up postoperatively. Results Vitrectomy was completed successfully in all 12 eyes (12/12) without uncontrolled retinal bleeding diffusion intraoperative. Postoperative IOP increased compared with preoperative values ( t=-4.710, P = 0.001), but it could be controlled by topic ophthalmic medication. Postoperative BCVA was significantly improved compared with preoperative values (t = 5.149, P = 0.000). No other significant complications were observed. Conclusion This surgical technique can effectively and rapidly restore the refractive media transparency in severe PDR surgery, ensuring the smooth progression of the operation.