Prospective study shows testosterone's impact on surgical outcomes in urethral stricture patients, indicating significant associations with wound infection and hemoglobin levels.
Purpose: Assessing the association between Testosterone (T)-level in patients with urethral stricture (US) and its effect on surgery outcome. Methods: This prospective study includes 70 cases of developing US disease and anastomotic Urethroplasty. All patients underwent retrograde and voiding urethrography, pelvi-abdominal ultrasound, and T (free and total) measurements. Results: A significant negative association was found between free T, age, and post-void residual volume (PVR) pre. Also, a positive association between free T and Hemoglobin (Hb) levels. Besides, an association between wound infection and total T. There was a significant lower in PVR and higher in Q-max post-urethroplasty than pre-urethroplasty. International prostate symptom score (IPSS) showed a significant decrease in post-urethroplasty and at 3 months follow up than pre-urethroplasty ( p < 0.05). Diabetes mellitus, free, and total T showed significant differences between the studied groups. Also, it can predict failure results respectively at cut-off ⩽123.75 and ⩽765.8 with 85.70% sensitivity, 98.40%, and 88.90% specificity. Conclusions: Diabetic status, wound infection, and free and total T significantly affect the success rate in patients with the US, while preoperative PVR, Q-max, and IPSS did not affect the success rate.
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Ismail et al. (2025) studied this question.
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