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This is a Quantitative Study study (also classified as: Experimental Study).

October 16, 2025PLoS ONEOpen Access

Quantification of timelapse 3D tumor spheroid killing activity of NK cells using a live-cell imaging system

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NK cell activity increases with higher effector-to-target ratios, leading to greater cancer cell death.
Live-cell imaging reveals distinct patterns of cell death between cholangiocarcinoma and triple-negative breast cancer cells.
This study employs a 3D spheroid model to better simulate tumor behavior compared to traditional 2D cultures.
The findings support the use of 3D spheroid models in developing NK cell-based immunotherapies.

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This study demonstrates NK cell-mediated cytotoxicity against 3D tumor spheroids, indicating a novel approach for immunotherapy.

Srisantitham et al. (2025) studied this question.

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