This case highlights an isolated eyelid myxoma with rapid growth in an elderly patient, suggesting careful monitoring and surgical intervention may be necessary.
An isolated eyelid myxoma is a very rare entity with a high risk of recurrence. Hence, it requires high diagnostic suspicion for adequate surgical planning with complete excision and suitable surgical safety margins, as well as proper monitoring for recurrence. We describe a rare case of an isolated cutaneous palpebral myxoma in a 78-year-old man who presented with a nodular lesion on the left eyelid margin that had shown rapidly progressive growth in the previous 8 months, without skin lesions on other parts of the body. The echocardiogram and comprehensive systemic evaluation were within normal limits. An excisional biopsy was done. The histological findings confirmed a cutaneous myxoma. Given the rarity of this condition, a pathologist plays a crucial role in the definitive diagnostic confirmation as well as for the appropriate management and follow-up approach, which includes appropriate systemic exploration to rule out conditions on the Carney complex syndromic spectrum.
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Padilla-Pantoja et al. (2025) studied this question.
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