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October 17, 2025BMJ OpenOpen Access

Pre-conception lifestyle intervention to optimise maternal health for a better start to life: the BEGIN BETTER prospective randomised controlled trial protocol

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Randomised controlled trial evaluates lifestyle intervention effects on maternal health and pregnancy outcomes.

The intervention improves maternal health pre-conception and aims to enhance birth outcomes for infants.
Primary outcome is infant birth weight z-score, with an estimated mean of 0.43 and recruitment of 800 women planned.
Women with a BMI ≥25.0 kg/m2 will participate in either the educational control or lifestyle intervention groups for 6 months.
Results will contribute to understanding the relationship between maternal lifestyle, obesity, and pregnancy outcomes.

Mitchell et al. (2025) studied this question.

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