Observational analysis finds reduced hepcidin in advanced colorectal cancer, suggesting iron dysregulation.
Highlights • CRC patients show lower hepcidin concentration than controls • Hepcidin is moderately linked to ferritin, reflecting iron dysregulation in colorectal cancer • Colorectal cancer patients have lower ferritin than controls • Hepcidin is lower in advanced tumor stage (T3 vs. T0) • C-reactive protein and interleukin-6 correlate weakly with hepcidin, suggesting other tumor effects
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Rolić et al. (2025) studied this question.
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