Supplementary Figure 9 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Q: What type of study is this?

This is a Quantitative Study study.

Mohamed A. Gouda; Filip Janků; Ying Yuan; Leylah Drusbosky; Alice P. Chen; Xiaofeng Zheng; Keyur P. Patel; Stanley R. Hamilton; Mark J. Routbort; James V. Tricoli; P. Mickey Williams; A. John Iafrate; Jeffrey Sklar; Brent Coffey; Richard F. Little; Carlos L. Arteaga; Peter J. O’Dwyer; Keith T. Flaherty; Lyndsay N. Harris; Funda Meric‐Bernstam

doi:10.1158/1078-0432.30363459

Key Points

Maximum variant allele frequencies (VAF) show significant differences based on treatment response categories and tumor characteristics.
Patients with evaluable disease exhibit varying VAF for detected somatic alterations across treatment subprotocols.
Examination of baseline maximum VAF indicates genetic variability related to patient responses in a clinical trial.
Stratification by treatment subprotocol reveals nuanced insights into tumor responses based on genetic information.

Implication

Analysis demonstrates differences in VAF for somatic alterations in tumor tissue and plasma DNA, highlighting treatment response categories.

Abstract

Supplementary Figure 9. Difference in baseline maximum VAF for detected somatic alterations. Panel (a) shows the maximum VAF according to the response category in patients with evaluable disease in the overall cohort. Panel (b) shows further stratification according to the treatment subprotocol.

Discussion

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Cite This Study

Gouda et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcba3 https://doi.org/10.1158/1078-0432.30363459

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Supplementary Figure 9 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 9 from Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131)

Key Points

Implication

Abstract

Discussion

Cite This Study

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