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October 17, 2025Current Pharmaceutical Design

Unveiling the Therapeutic Targets and Active Components of Xianlinggubao Capsule in Osteoarthritis and Osteoporosis through Network Pharmacology and Bioinformatics Analysis

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Authors

QMQing MaXMXuhui MaXHXuejiao Hua

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Overview

Bioinformatics and network pharmacology reveal key genes and pathways linked to osteoarthritis and osteoporosis.

Key Points

  • Bioinformatics identified 473 unique genes related to osteoarthritis and osteoporosis, suggesting common therapeutic mechanisms.
  • Network pharmacology found 30 intersecting genes, establishing them as principal targets for treating osteoarthritis and osteoporosis.
  • Key interactions were confirmed through molecular docking, highlighting danshenxinkun B and miltirone as effective agents.
  • Evaluation of cellular experiments supports the modulation of gene expression through the identified therapeutic targets.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcbc2https://doi.org/10.2174/0113816128406157250911093530
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the pharmacological mechanism of Xianlingubao against diabetic osteoporosis based on network pharmacology and molecular docking: An observational study2024 · 3 citations
  2. 2A network pharmacology approach to explore and validate the potential targets of ginsenoside on osteoporosis2022 · 7 citations
  3. 3Study on the Mechanism of Action of the Traditional Chinese Medical Prescription Gushukang in Treating Osteoporosis Based on Network Pharmacology and Experimental Verification2024 · 2 citations
  4. 4Network pharmacology, bioinformatics, molecular docking and experimental verification of the mechanism of HXZTS treatment on osteoarthritis synovium2025
  5. 5Multi-layered Network Analysis of Osteoking in the Treatment of Osteoporosis: Unraveling Mechanisms from Gene Expression to Molecular Docking2024