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October 15, 2025Open Access

Supplementary Figure S3 from ARID1A Loss plus CD8⁺ T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma

Zhaopei Liu Lingkai Zhang Kaifeng Jin Han Zeng Xiaohe Su Yawei Ding Jiaxing Sun Yuzhen Wu Hailong Liu Yu Zhu Le Xu Weijuan Zhang Zewei Wang Yuan Chang Jiejie Xu

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Key Points

ARID1A loss is linked to improved clinical outcomes in urothelial carcinoma, enhancing patient prognosis.
Increased CD8+ T-cell infiltration correlates with favorable outcomes, suggesting immune response is beneficial.
The study highlights the relationship between ARID1A status and tumor mutation burden, important for treatment strategies.
Findings support the role of immune factors like T-cell infiltration in determining the prognosis of urothelial carcinoma.

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Implication

Analysis associates ARID1A loss and T-cell infiltration with improved clinical outcomes in urothelial carcinoma.

Abstract

Association between ARID1A status and TMB in UC.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcc4f https://doi.org/10.1158/1078-0432.30363424

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from ARID1A Loss plus CD8<sup>+</sup> T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma2025
2Supplementary Figure S4 from ARID1A Loss plus CD8<sup>+</sup> T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma2025
3Data from ARID1A Loss plus CD8<sup>+</sup> T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma2025
4ARID1A loss plus CD8+ T cell infiltration associate with favorable clinical outcomes in urothelial carcinoma.2025 · 1 citations
5Supplementary Figure S1 from ARID1A Loss plus CD8<sup>+</sup> T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma2025