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October 17, 2025Frontiers in ImmunologyOpen Access

Omega-3 fatty acid synergy with glucocorticoid in mouse lupus macrophage model: targeting pathogenic pathways to reduce steroid dependence

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DHA and low-dose DEX reduced inflammatory gene expression in mouse lupus model, indicating synergy.
Suboptimal DHA concentrations amplified DEX efficacy by 10- to 100-fold against ISG activation.
Combined DHA and DEX cotreatment identified hundreds of differentially expressed genes linked to inflammation resolution.
Strategically targeting macrophage pathways suggests potential for reducing steroid use in SLE treatment.

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Implication

Analysis shows omega-3 fatty acids enhance glucocorticoid treatment effects in lupus macrophages, highlighting potential for steroid-sparing strategies.

Cite This Study

Heine et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dce8b https://doi.org/10.3389/fimmu.2025.1646133

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Implication

Analysis shows omega-3 fatty acids enhance glucocorticoid treatment effects in lupus macrophages, highlighting potential for steroid-sparing strategies.

Omega-3 fatty acid synergy with glucocorticoid in mouse lupus macrophage model: targeting pathogenic pathways to reduce steroid dependence

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Discussion

Implication

Cite This Study

Omega-3 fatty acid synergy with glucocorticoid in mouse lupus macrophage model: targeting pathogenic pathways to reduce steroid dependence

Key Points

Discussion

Implication

Cite This Study

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