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October 17, 2025Open Access

Formulation and Characterization of PLGA Minocycline Microneedles for Enhanced Skin Deposition and Antibacterial Activity in Acne Treatment

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Authors

JEJuhaina M. Abu ErshaidSASuha Mujahed AbudolehDLDima N. Lafi

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Overview

Formulation of minocycline microneedles enhances skin deposition and shows significant antibacterial activity, suggesting a novel acne treatment method.

Key Points

  • Microneedles delivered minocycline effectively into the skin, showing potential as a safer acne treatment.
  • About 26% of the minocycline was deposited into the skin, significantly higher than the 18.3% that permeated through it.
  • The use of microneedles reduces the risk of systemic side effects and bacterial resistance compared to traditional methods.
  • Insertion tests showed minimal height reduction, indicating good mechanical strength and effective skin penetration.

Cite This Study

Ershaid et al. (2025) studied this question.

synapsesocial.com/papers/68f199ccde32064e504dd121https://doi.org/10.20944/preprints202510.1216.v1
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