New MCR for the Rapid Construction of Polysubstituted Pyridines in Aqua Media Using (Bu₃Sn)₂MoO₄ as Green and Sustainable Catalyst

A new combinatorial, rapid and single‐pot multi‐component sequence is developed for the synthesis of polysubstituted pyridines by using organotin‐oxomolybdate coordination polymer as green catalyst in aqua media. New MCR utilizes benzaldehyde, ethynylbenzene / ethyl but‐2‐ynoate, amine / alcohol and malononitrile as components to produce diversified pyridines with excellent yields (94%–97%) using 10 mol% of (Bu 3 Sn) 2 MoO 4 catalyst in water at ambient temperature. All the isolated products are characterized by 1 H NMR, 13 C NMR, IR and Mass data. The catalyst was recovered and reused as many as six times without loss of activity. New protocol is scale amicable and compatible with broad range of substrates.