Classical transition state theory (TST) struggles with enzyme non-Arrhenius behavior and large, weakly temperature-dependent tunneling KIEs. 1–3 Building on Manuscript 1 (ChemRxiv v3), 4 we report TDSE wavepacket sweeps in two phases. Phase I (36 conditions; PCET I excluded) identifies the funnel (H) as uniquely robust for sustained aperture formation. Phase II fixes H and enumerates all two-factor pairs from B, C, D, E, F, G, I, J (28 panels), revealing a dominant H+C (uniform field) synergy that maintains continuous flux under decoherence. The motif aligns with vibronic and ET observables and yields testable predictions (2D-IR, polarization). We connect gated resonators to UPE readouts, 5–7 situate helicity responses (CISS) within the same resonance grammar, 8, 9 and outline a Proof-of-Resonance cryptographic layer for dataset provenance. 10–12
J. R. Sutton (Wed,) studied this question.
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