October 17, 2025Angewandte Chemie International Edition

Counteranion‐Controlled Chemodivergent Transfer‐Hydrothiolation/Carbothiolation Using Thioethers as Bifunctional Reagents

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Authors

ZWZhen WangBeijing Institute of Technology HTHao‐Dong Tan YWYao‐Xin WangBeijing Institute of Technology

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Implication

Observational analysis reveals chemodivergence in hydrothiolation and carbothiolation using thioethers, indicating potential for pharmaceutical applications.

Key Points

The study demonstrates that counteranion choice influences C( sp 3 )─S bond formation's outcome.
By using TfO − as a counteranion, an unusual Markovnikov transfer can occur with thioethers.
The research conducted mechanistic studies to understand how counteranion coordination affects thiolate basicity.
Findings suggest that noncoordinating counteranions enable a new thioether-ene reaction across alkenes.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68f199d1de32064e504dd536 https://doi.org/10.1002/anie.202516277

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Implication

Observational analysis reveals chemodivergence in hydrothiolation and carbothiolation using thioethers, indicating potential for pharmaceutical applications.

Counteranion‐Controlled Chemodivergent Transfer‐Hydrothiolation/Carbothiolation Using Thioethers as Bifunctional Reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

Counteranion‐Controlled Chemodivergent Transfer‐Hydrothiolation/Carbothiolation Using Thioethers as Bifunctional Reagents

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider