An ultrasensitive sandwich-type electrochemical immunosensor for PSA detection: employing layer-by-layer self-assembly with poly(thionine)/carbon nanotube multilayers as electron mediators and hemin-functionalized PEI/SiO2 nanoparticles as signal amplifiers

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This is a Experimental Study study.

Zheng Chang; Zhiguang Duan; Junpeng Li; Xianming Meng

doi:10.1039/d5ay01330e

January 1, 2025Analytical Methods

An ultrasensitive sandwich-type electrochemical immunosensor for PSA detection: employing layer-by-layer self-assembly with poly(thionine)/carbon nanotube multilayers as electron mediators and hemin-functionalized PEI/SiO2 nanoparticles as signal amplifiers

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Key Points

The immunosensor achieved ultrasensitivity for detecting prostate-specific antigen, showing promising results for early diagnosis of prostate cancer.
Key evidence includes the effectiveness of hemin-functionalized nanoparticles as an electrochemical label, enhancing detection sensitivity significantly.
The approach utilized layer-by-layer self-assembly with poly(thionine) and carbon nanotubes, combined with hemin-functionalized nanoparticles as amplifiers.
The findings highlight potential improvements in prostate cancer diagnostics through advanced electrochemical methods, indicating important future research avenues.

Abstract

In this study, hemin-functionalized polyethyleneimine/silica nanoparticles (hemin/PEI/SiO2 NPs) served as an electrochemical label for ultrasensitive detection of prostate-specific antigen (PSA), a clinically important prostate cancer biomarker. A poly(thionine)/carbon nanotube (PTh/CNTs)...

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Chang et al. (2025) studied this question.

synapsesocial.com/papers/68f19f20de32064e504ddbea https://doi.org/10.1039/d5ay01330e

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An ultrasensitive sandwich-type electrochemical immunosensor for PSA detection: employing layer-by-layer self-assembly with poly(thionine)/carbon nanotube multilayers as electron mediators and hemin-functionalized PEI/SiO2 nanoparticles as signal amplifiers

Key Points

Abstract

Discussion

Cite This Study

An ultrasensitive sandwich-type electrochemical immunosensor for PSA detection: employing layer-by-layer self-assembly with poly(thionine)/carbon nanotube multilayers as electron mediators and hemin-functionalized PEI/SiO2 nanoparticles as signal amplifiers

Key Points

Abstract

Discussion

Cite This Study

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