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October 17, 2025DermatopathologyOpen Access

Cutaneous Neufibroma in the Absence of Classical NF1 Features: A Case Report and Literature Review

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Authors

CSChristine Suryani Novelita SutrisnoDPDesy Hinda PramitaIDIta Puspita Dewi

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Overview

Case report highlights atypical manifestations of neurofibromatosis type 1 in adults, suggesting revised diagnostic criteria.

Key Points

  • Multiple cutaneous neurofibromas were present in a 47-year-old male without typical neurofibromatosis type 1 features.
  • Histopathological examination confirmed the diagnosis of cutaneous neurofibroma, although the patient did not meet NIH guidelines for NF1 diagnosis.
  • The findings emphasize the need for heightened clinical suspicion of atypical NF1 phenotypes in adults, despite lacking early-life signs.
  • The case raises awareness about the psychosocial impacts of widespread cutaneous neurofibromas and the limitations of existing diagnostic paradigms.

Cite This Study

Sutrisno et al. (2025) studied this question.

synapsesocial.com/papers/68f19f20de32064e504ddc51https://doi.org/10.3390/dermatopathology12040037
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