October 1, 1996AJP Regulatory Integrative and Comparative Physiology

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats

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Authors

MTMads Tang‐ChristensenNovo Nordisk (Denmark)PLPhilip J. LarsenOregon National Primate Research Center RGRüdiger GökePhilipps University of Marburg

Discussion

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Implication

Preclinical study demonstrates reduced food and water intake following central GLP-1 administration in rats, suggesting a regulatory role in fluid and energy homeostasis.

Key Points

Central administration of GLP-1 suppresses food intake in food-restricted rats and profoundly inhibits angiotensin ii-induced drinking behavior without altering locomotion.
Analysis using intracerebroventricular injection and peripheral administration compared active peptides against inactive forms across feeding schedules in rats.
Findings highlight that central GLP-1 signaling may regulate ingestive behavior and urinary excretion; rat model limits direct clinical extrapolation to humans.

Cite This Study

Tang‐Christensen et al. (1996) studied this question.

synapsesocial.com/papers/68f2b2ccb8fb99049eea7c3f https://doi.org/10.1152/ajpregu.1996.271.4.r848

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Implication

Preclinical study demonstrates reduced food and water intake following central GLP-1 administration in rats, suggesting a regulatory role in fluid and energy homeostasis.

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider