March 1, 2003Journal of Biological ChemistryOpen Access

A G Protein-coupled Receptor Responsive to Bile Acids

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Identification of TGR5 establishes a cell-surface G protein-coupled receptor responsive to bile acids, which directly triggers intracellular cAMP production and receptor internalization.
Median effective concentrations of 0.33 to 7.72 μm enabled bile acids to stimulate cAMP production in transfected cells, and treatment markedly reduced cytokine secretion.
Highlights a direct immunosuppressive mechanism of bile acids via TGR5 activation in alveolar macrophages; preclinical cell model, further in vivo confirmation is warranted.

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Implication

Experimental study demonstrates that bile acids activate cell-surface receptor TGR5 in monocytes and alveolar macrophages, indicating a mechanism for bile acid-induced immunosuppression.

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Kawamata et al. (2003) studied this question.

synapsesocial.com/papers/68f2b2d4b8fb99049eea7c50 https://doi.org/10.1074/jbc.m209706200

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Implication

Experimental study demonstrates that bile acids activate cell-surface receptor TGR5 in monocytes and alveolar macrophages, indicating a mechanism for bile acid-induced immunosuppression.

A G Protein-coupled Receptor Responsive to Bile Acids

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A G Protein-coupled Receptor Responsive to Bile Acids

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Implication

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