Ligand-centered redox driven Zn(II)-catalyzed anti-markovnikov hydroamination of activated alkenes with primary aromatic amines via aminium radical cations

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This is a Experimental Study study.

Subhasree Pal; Santana Chakraborty; Azra Pervin; Nanda D. Paul

doi:10.1039/d5qo01248a

January 1, 2025Organic Chemistry Frontiers

Ligand-centered redox driven Zn(II)-catalyzed anti-markovnikov hydroamination of activated alkenes with primary aromatic amines via aminium radical cations

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Key Points

The study reveals a Zn(II)-catalyzed approach for anti-Markovnikov hydroamination, transforming various electron-deficient alkenes.
A defined catalytic system with a redox-active arylazo-phenanthroline ligand enables significant hydroamination reactions.
The method features a novel ligand-centered redox-driven mechanism involving aminium radical cations for reaction progression.
This catalytic approach may influence future strategies for selective hydroamination in organic synthesis.

Implication

This method demonstrates anti-Markovnikov hydroamination in electron-deficient alkenes, suggesting a novel ligand-centered approach.

Abstract

A ligand-centered redox-driven strategy for anti-Markovnikov hydroamination of electron-deficient alkenes including acrylates, acrylonitrile, and acrylamides-enabled by a well-defined Zn(II)-catalyst bearing a redox-active arylazo-phenanthroline ligand is reported.The azo-functionalized ligand serves as...

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Cite This Study

Pal et al. (2025) studied this question.

synapsesocial.com/papers/68f35bfc73f0a7d050f47d6c https://doi.org/10.1039/d5qo01248a

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Ligand-centered redox driven Zn(II)-catalyzed anti-markovnikov hydroamination of activated alkenes with primary aromatic amines via aminium radical cations

Key Points

Implication

Abstract

Discussion

Cite This Study

Ligand-centered redox driven Zn(II)-catalyzed anti-markovnikov hydroamination of activated alkenes with primary aromatic amines via aminium radical cations

Key Points

Implication

Abstract

Discussion

Cite This Study

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