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October 18, 2025Journal of Clinical MedicineOpen Access

Outcomes of Living-Donor Liver Transplantation for Cholangiocarcinoma Versus Hepatocellular Carcinoma in the United States

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Authors

MGMerve GürakarÖÖÖzge ÖzgürADAyse Eylul Donmez

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Overview

Observational analysis shows lower post-LDLT survival for cholangiocarcinoma patients versus hepatocellular carcinoma, highlighting significant survival differences.

Key Points

  • At 5 years post-LDLT, cholangiocarcinoma patients have significantly lower survival (62.2%) than those with hepatocellular carcinoma (78.2%).
  • Among 3993 LDLT recipients, only 102 patients had cholangiocarcinoma, accounting for just 2.6% of cases compared to 19.4% for hepatocellular carcinoma.
  • Kaplan–Meier analysis was used to determine post-LDLT survival outcomes for cholangiocarcinoma and hepatocellular carcinoma patients.
  • Long-term results suggest that living-donor liver transplantation may offer different prognoses depending on the type of liver cancer diagnosed, necessitating tailored approaches.

Cite This Study

Gürakar et al. (2025) studied this question.

synapsesocial.com/papers/68f35bfc73f0a7d050f47e48https://doi.org/10.3390/jcm14207306
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term outcomes in deceased versus living donor liver transplantation for hepatocellular carcinoma: a bi-institutional study of 486 cases2025 · 1 citations
  2. 2Comparative Review of LDLT and DDLT Outcomes in Hepatocellular Carcinoma Patients2025
  3. 3Outcomes of liver transplantation for hepatocelluler carcinoma from living donor versus deceased donor within University of Southern California San Francisco criteria: a report from Turkey2024 · 2 citations
  4. 4The role of living donor liver transplantation in treating intrahepatic cholangiocarcinoma2024 · 3 citations
  5. 5Indications and Outcomes of Liver Transplantation for Liver Tumors in the United States.2024 · 2 citations