What type of study is this?

This is a Animal Study study (also classified as: Experimental Study).

October 18, 2025PLoS ONEOpen Access

Electroacupuncture alleviates pain-like behaviors through modulating DNMT3a/MOR signaling pathway in CCI rats

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Electroacupuncture demonstrates effectiveness in pain relief for neuropathic pain, suggesting a role for DNMT3a and MOR signaling pathways.

Electroacupuncture significantly increased the paw withdrawal threshold in chronic constriction injury rats.
Chronic constriction injury elevated DNMT3a levels while decreasing MOR levels, which was reversed by electroacupuncture.
The study employed western blotting and RT-qPCR methods to analyze expression changes in pain-related signals.
Findings suggest electroacupuncture may alleviate pain by enhancing MOR expression and inhibiting DNMT3a.

Wang et al. (2025) studied this question.

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Electroacupuncture demonstrates effectiveness in pain relief for neuropathic pain, suggesting a role for DNMT3a and MOR signaling pathways.