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This is a Quantitative Study study (also classified as: Cohort Study).

October 18, 2025Hypertension

Abstract TAC274: Functional Ca ²⁺ signaling is regulated by histamine in glomerular podocytes

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Functional analysis reveals that histamine induces Ca 2+ transients in podocytes, indicating possible roles of H receptors.

Histamine elicits acute Ca 2+ transients in rat podocytes, primarily mediated through intracellular stores.
Peak responses show no significant difference in CaCl 2 conditions, while AUC values indicate different intracellular contributions.
Inhibition of TRPC6 channels did not affect Ca 2+ transient sizes, suggesting alternative pathways are involved.
An H2 receptor antagonist dampened Ca 2+ peak responses, pointing to specific histaminergic signaling roles in kidney function.

Andrews et al. (2025) studied this question.

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