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October 18, 2025Hypertension

Abstract FR449: Intensive Systolic Blood Pressure Lowering Reduces Major Cardiovascular Events: A Meta-Analysis of 83,580 Patients

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Authors

JNJunaid NawabSSShah‐Jalal SarkerSBSoirindhri Banerjee

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Overview

Meta-analysis shows that targeting systolic BP <130 mmHg lowers cardiovascular events in patients, suggesting improved outcomes.

Key Points

  • Intensive lowering of systolic blood pressure significantly reduces major cardiovascular events.
  • The risk of cardiovascular death is decreased with intensive BP targets, showing a relative risk of 0.73.
  • Intensive BP lowering also significantly decreases the risk of stroke and heart failure.
  • While intensive treatment raises hypotension incidents, serious adverse events were not increased.

Cite This Study

Nawab et al. (2025) studied this question.

synapsesocial.com/papers/68f3b2fb3f213c1f8b4d36fdhttps://doi.org/10.1161/hyp.82.suppl_1.fr449
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis2012 · 780 citations
  2. 2Systolic blood pressure targets below 120 mm Hg are associated with reduced mortality: A meta‐analysis2025 · 13 citations
  3. 3Impact of intensive versus standard blood pressure control on cardiovascular events in hypertensive patients: a meta-analysis of randomized controlled trials2025 · 1 citations
  4. 4Effect of intensive versus standard blood pressure control on cardiovascular outcomes: a meta-analysis of randomized controlled trials.2026
  5. 5Impact of Intensive Blood Pressure Control Versus Standard Control on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2025 · 2 citations