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January 1, 2025RSC AdvancesOpen Access

Copper acetate mediated thiomethylation of 2-pyridine-substituted acrylonitriles with DMSO

Min Ye Jie Yang Cheng Huang Zhengwang Chen

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Key Points

This synthesis method produces alkenyl methyl thioethers efficiently using copper acetate.
The process uses DMSO as a methylthio source, effectively facilitating the C–H functionalization step.
Thiomethylation is achieved on 2-pyridine-substituted acrylonitriles, demonstrating the technique's versatility.
Potential applications include expanding the use of DMSO in generating sulfur-containing compounds.

Implication

Direct C–H functionalization generates alkenyl methyl thioethers from acrylonitriles, suggesting DMSO's utility.

Abstract

An efficient synthesis of alkenyl methyl thioethers through direct C–H functionalization from acrylonitriles with DMSO as the methylthio source.

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Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/68f3eb011cfc5ad53f2907d5 https://doi.org/10.1039/d5ra07270k

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