3C. 3-Ketosteroid receptors in GtoPdb v.2025.3

Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 221, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol. Clinically-used drugs interacting with the 3-ketosteroid receptors include testosterone (AR), methylprednisolone (GR), eplerenone (MR), and medroxyprogesterone (PR).