The study reports the unique composition of full and half transporters in the ABCB subfamily, suggesting insights into drug resistance mechanisms.
The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [8, 1].
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Mary Vore (2025) studied this question.
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