Inhibition of inosine monophosphate dehydrogenase in Lassa fever management by phenolics from (Telfairia Occidentalis ), an edible plant in Nigeria, using computational analysis

Busayo Christiana Ihinmikaye; Olusola Olalekan Elekofehinti; Moses Orimoloye Akinjiyan; Isaac Ihinmikaye; Adeola George-Ojo

doi:10.37432/jieph-confpro5-00267

September 8, 2025Journal of Interventional Epidemiology and Public HealthOpen Access

Inhibition of inosine monophosphate dehydrogenase in Lassa fever management by phenolics from (Telfairia Occidentalis ), an edible plant in Nigeria, using computational analysis

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Key Points

The study identifies six phenolic compounds with strong binding affinity to IMPDH, which could be developed for lassa fever therapy.
Predicted IC50 values for the lead compounds range from 5.035 to 4.597, suggesting their bioactivity is better than Ribavirin's 3.404.
Molecular docking and pharmacokinetic analyses were employed to evaluate the inhibitory potential of these compounds on IMPDH.
These compounds passed Lipinski’s rule of five, indicating good pharmacokinetic properties for further therapeutic development.

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Implication

Computational analysis reveals six phenolic compounds with promising binding affinity for inosine monophosphate dehydrogenase, suggesting new therapy avenues for lassa fever.

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Ihinmikaye et al. (2025) studied this question.

synapsesocial.com/papers/68f3eb011cfc5ad53f29094c https://doi.org/10.37432/jieph-confpro5-00267

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Inhibition of inosine monophosphate dehydrogenase in Lassa fever management by phenolics from (Telfairia Occidentalis ), an edible plant in Nigeria, using computational analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Inhibition of inosine monophosphate dehydrogenase in Lassa fever management by phenolics from (Telfairia Occidentalis ), an edible plant in Nigeria, using computational analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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