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Dual β-lactam synergy in Enterococcus faecalis and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes

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No statistical difference in treatment outcomes between benzylpenicillin-ceftriaxone and other therapies was observed.
GDS was an unreliable predictor of synergy, while double disc diffusion showed reasonable accuracy.
Thirty-eight episodes of infective endocarditis were included, primarily treated with benzylpenicillin-ceftriaxone.
Ceftriaxone susceptibility predicts benzylpenicillin-ceftriaxone synergy in E. faecalis isolates from a comorbid cohort.

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Retrospective cohort correlates synergy of benzylpenicillin-ceftriaxone in infective endocarditis, suggesting predictors may vary.

Gregson et al. (2025) studied this question.

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