What type of study is this?

This is a Systematic Review study.

October 19, 2025BiomoleculesOpen Access

The Role of Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) in Hemoglobinopathy Management—Techniques, Accuracy, and the Balancing of Benefits and Drawbacks

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Comprehensive review examines PGT-M techniques and accuracy for hemoglobinopathies, highlighting implications of allele drop-out.

PGT-M significantly improves embryo selection for hemoglobinopathy management, offering preventative strategies before conception.
Review of 22 articles identifies multiple displacement amplification as an effective WGA method with manageable allele drop-out rates.
Use of next-generation sequencing enhances diagnostic accuracy in PGT-M by integrating genetic markers to address amplification challenges.
Future advancements in non-invasive PGT methods could provide alternative approaches, expanding accessibility to genetic testing.

Chantrasiri et al. (2025) studied this question.

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