HBV And HCV Related HCC- Experience At Model Treatment Centre

Introduction: Hepatocellular Carcinoma (HCC) is one of the most common malignant tumours in the world. The various risk factors include hepatitis B &C viruses, alcohol, metabolic syndrome including diabetes mellitus, chemicals, and inborn and acquired metabolic disease. HCC is closely associated with hepatitis B and C virus because liver injury caused by viral factor affects many cellular processes such as cell signaling, apoptosis, transcription, DNA repair which in turn induce important effects on cell survival, growth, transformation and maintenance. Material and Methods: This was a prospective study done at Medical Gastroenterology Department, PGIMS,Rohtak conducted over a period of five years i.e. 01.08.2020 to 31.07.2025, during which patients diagnosed to be having HCC due to HBV and HCV were enrolled into study, after written consent for the same. The data pertaining to eighty HCC patients, fourty each of HBV and HCV was analyzed. Observations and Results: HBV and HCV related H.C.C is commonly seen in males and older age group. In Hepatitis B group, out of 40 patients, 32 patients (80%) were above 50 yrs of age. The two patients who belonged to third decade were non cirrhotic and were having chronic hepatitis B with high viral load and directly developed multifocal H.C.C without going into cirrhotic stage. Rest all 38 patients of HBV were cirrhotic. In Hepatitis C group, out of 40 patients, 23 patients (90%) were above 50 yrs of age. Out of 40 HCV patients, 39 were cirrhotic but one 19 years old female was non-cirrhotic and this may be the first case of HCV which has developed HCC without going to cirrhotic stage. Conclusion: Good compliance on drugs is mandatory and patients should be strictly prohibited against smoking and alcohol intake which increases the risk of developing HCC. Females with HBV and HCV requires strict vigil, as they may develop HCC with low viral loads in HBV and even non-cirrhotic can develop HCC in background of HCV. Due to efforts under NVHCP, the need of liver transplant is decreasing steadily in HBV and HCV group.