Retrospective study compares cardiorespiratory stability between medetomidine-ketamine and medetomidine-tiletamine-zolazepam protocols in baboons during laparoscopic procedures.
Laparoscopic salpingectomy is a mini-invasive surgery that requires careful anaesthesiologic management due to impact of pneumoperitoneum. In this retrospective study baboons (Papio Hamadryas) were treated with two sedative protocols: medetomidine-ketamine (MK; n=14) or medetomidine-tiletamine-zolazepam (MZ; n=12) via intramuscular injection. A laryngeal mask (LMA) was used for airway management and anaesthesia was maintained with isoflurane. For statistical analysis were considered and analysed via two-way ANOVA: heart rate (HR), respiratory rate (RR), systolic, diastolic and mean arterial blood pressure (SAP, DAP, MAP), end-tidal carbon dioxide (EtCO₂) and peripheral saturation (SpO₂) recorded five minutes before pneumoperitoneum (PREP), immediately after abdominal insufflation (PP1), at 10 (PP2), 20 (PP3) minutes post-insufflation and 5 minutes after pneumoperitoneum interruption (POSTP). HR and RR were statistically significantly higher (p < 0.05) in MK group compared to MZ group at all time points of the study. EtCO₂ was significantly higher (p < 0.05) in MZ group at PP2, PP3, and POSTP time points. The incidence of hypotension was significantly greater in MZ group (45.5%) compared to MK group (6.25%). Hypercapnia was observed in all baboons sedated with MZ protocol compared to 12.5% of MK group. As a result, MK protocol provides greater cardiorespiratory stability during laparoscopic surgery.
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Pizzi et al. (2025) studied this question.
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