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October 19, 2025Translational PsychiatryOpen Access

Cortical gyrification predicts initial treatment response in adults with ADHD

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Authors

JLJonathan LaatschUniversity Hospital BonnFSFrederike SteinPhilipps University of MarburgSMSimon MaierUniversity of Freiburg

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Implication

Analysis uncovers associations between cortical gyrification and treatment response in adults with ADHD, suggesting implications for personalized approaches.

Key Points

  • Increased cortical gyrification predicts better treatment response in adults with ADHD, especially in the frontal regions.
  • Significant positive associations were found between cortical gyrification and treatment response across three symptom dimensions.
  • Linear regression models highlighted the prognostic value of pre-treatment cortical structure on post-treatment severity.
  • Findings indicate that cortical gyrification could serve as a biological marker for effective ADHD treatment strategies.

Cite This Study

Laatsch et al. (2025) studied this question.

synapsesocial.com/papers/68f500b442a2eee15b0a0e20https://doi.org/10.1038/s41398-025-03681-0
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Also Consider

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