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October 20, 2025Cell TransplantationOpen Access

Age- and comorbidity-adjusted busulfan, fludarabine, cytarabine, and low-dose TBI-based conditioning regimen is effective for myelodysplastic syndromes with excess blasts undergoing allogeneic peripheral blood stem cell transplantation

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Authors

JGJie GaoXuzhou Medical CollegeHWHuixian WuSun Yat-sen UniversityHQHuiying QiuShanghai Jiao Tong University

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Implication

Retrospective analysis demonstrates high engraftment and low relapse rates in MDS patients, indicating tailored conditioning regimens can improve outcomes.

Key Points

  • The conditioning regimen led to successful engraftment in all patients, with median neutrophil and platelet engraftment at 12 and 13 days, respectively.
  • The 2-year overall survival was reported at 81.9%, alongside progression-free survival of 77.3% and low 2-year relapse incidence of 11.5%.
  • The age- and comorbidity-adjusted regimen, featuring busulfan and fludarabine, showed less impact from conditioning intensity on survival outcomes.
  • IPSS-M emerged as a significant predictor of progression-free survival, emphasizing the biological aspects of the disease over conditioning factors.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68f58f68ece7a5b64f4715fchttps://doi.org/10.1177/09636897251380928
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fludarabine, busulfan, and melphalan conditioning regimen in allogeneic hematopoietic stem cell transplantation for adult patients with myeloid malignancies: A multicenter retrospective study2024 · 5 citations
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  3. 3Definitions of Cytomegalovirus Infection and Disease in Transplant Recipients2002 · 1,244 citations
  4. 4Impact of total body irradiation on successful neutrophil engraftment in unrelated bone marrow or cord blood transplantation2016 · 42 citations
  5. 5Dose-Reduced Versus Standard Conditioning Followed by Allogeneic Stem-Cell Transplantation for Patients With Myelodysplastic Syndrome: A Prospective Randomized Phase III Study of the EBMT (RICMAC Trial)2017 · 254 citations