October 20, 2025Journal of Dental ResearchOpen Access

Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity

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Authors

MMMuhammed ManzoorUniversity of Helsinki JPJukka PutaalaVascular / Pulmonary Vascular SZSvetislav ZarićKing's College London

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Implication

This study demonstrates links between oral microbiome diversity and LPS activity in saliva and serum, suggesting implications for oral and systemic health.

Key Points

Salivary alpha diversity shows a positive association with serum LPS activity but a negative one with salivary LPS.
Identified 10 taxa linked to serum LPS and 59 to salivary LPS, with Prevotella and Porphyromonas having significant positive associations.
A multicenter case-control study with metagenomic sequencing was used to analyze the oral microbiome's role in LPS levels.
Results suggest that dysbiosis of the oral microbiome contributes to increased LPS activity, affecting both saliva and serum.

Cite This Study

Manzoor et al. (2025) studied this question.

synapsesocial.com/papers/68f58f68ece7a5b64f471640 https://doi.org/10.1177/00220345251370995

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Implication

This study demonstrates links between oral microbiome diversity and LPS activity in saliva and serum, suggesting implications for oral and systemic health.

Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity

Discussion

Member takes

Implication

Key Points

Cite This Study

Oral Microbial Determinants of Saliva and Serum Lipopolysaccharide Activity

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider