Exploratory analysis compares sleep quality improvements in 17 adults using GABA and casein hydrolysate versus melatonin, suggesting enhanced deep sleep effects.
Sleep difficulty is relatively common among people, and those affected often resort to short-term use of herbal supplements to ease the symptoms. Here we introduce and investigate the effects of a novel composite product, NatureU Sleep, that contains sustained-release gamma-aminobutyric acid (GABA) and alpha-s1 casein hydrolysate, on sleep quality compared to the commercially available drug-melatonin. The exploratory clinical trial was designed to assess the deep sleep conditions including 17 adult participants, with an expectation that 15 would complete the trial. Utilizing wearable monitoring devices, the study evaluates the impact of the test product on deep sleep duration and proportion. The results indicated a significant increase in deep sleep duration and proportion for participants consuming sustained-release GABA and alpha-s1 casein hydrolysate, suggesting its potential as an effective sleep aid without any observed adverse events. This study aimed to compare the acute effects of a single dose of NatureU Sleep versus a single dose of commercial melatonin on objective measures of deep sleep.
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Lucas Law (2025) studied this question.
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