Risk factors for detecting germline BRCA1 and BRCA2 founder mutations in Ashkenazi Jewish women with breast or ovarian cancer

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Carriers of BRCA1 or BRCA2 mutations were found in 15.8% of breast cancer cases and 7.7% of ovarian cases, highlighting a significant mutation presence.
Age at diagnosis for mutation carriers was 44.6 years, significantly lower than the 52.1 years for non-carriers, showing a clear trend in age and mutation risk.
Logistic regression analysis was used to correlate personal and family history factors with mutation status, aiding in risk assessment for Ashkenazi Jewish women.
Family history was significant, with a third of mutation carriers having no relatives affected by breast or ovarian cancer, indicating potential for missed diagnosis.

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Logistic regression identifies risk factors for germline BRCA1 and BRCA2 mutations in breast and ovarian cancer cases among Ashkenazi Jewish women.

Hodgson et al. (1999) studied this question.

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Logistic regression identifies risk factors for germline BRCA1 and BRCA2 mutations in breast and ovarian cancer cases among Ashkenazi Jewish women.