Robust inference for stochastic dynamical systems is often hampered by sparse sampling and the absence of closed-form likelihoods. We introduce a Monte Carlo path-inference framework that leverages full-path statistics and bridge processes to deliver reliable parameter estimation and model selection from coarsely sampled time series, without requiring analytical solutions. Crucially, we couple mechanistic stochastic models with their inference procedures to quantify how experimental design -specifically, sampling frequency and dataset size- governs estimator precision and model distinguishability. This analysis reveals optimal sampling regimes and sharp, resolution-dependent limits beyond which competing models become empirically indistinguishable. We validate the approach across four disparate systems -trajectories of optically trapped particles, human microbiome dynamics, social-media topic mentions, and forest population time series- recovering parameters and identifying when inference is fundamentally constrained by measurement resolution, thereby clarifying ongoing debates about dominant noise sources in these systems. Together, these results establish path-based Monte Carlo as a practical, general tool for inference and model discrimination in complex systems and provide principled guidelines for designing measurements that maximize information under real-world constraints.
Aguilar et al. (Mon,) studied this question.