The effect of Aqua Myrgorod Detox mineral water on the gallbladder motility and biochemical parameters of blood serum in patients with biliary dysfunction

Background. Functional biliary dysfunction is a common disorder of gallbladder motility and significantly reduces the quality of life of patients. Current therapeutic strategies remain limited, which emphasizes the need to find safe non-drug approa­ches. One of the promising areas is the use of mineral waters that can influence gallbladder motility, mineral balance, and oxidative stress processes. The aim is to evaluate the effect of Aqua Myrgorod Detox mineral water on gallbladder motility and serum biochemical parameters in patients with biliary dysfunction. Materials and methods. The study included 10 patients with biliary dysfunction (mean age was (48.0 ± 2.25) years). For 7–8 days, they received Aqua Myrgorod Detox mineral water in a dose of 200 ml three times a day. Before and after the course, a clinical examination, gallbladder ultrasound with determination of the volume and contractile function, as well as laboratory analysis of macro- (Ca, Mg, Na, K) and microelements (Cu, Fe) and lipid peroxidation products were performed. In addition, integral coefficients (Na/K, Ca/Mg, Cu/Fe, MDA/Mg) were calculated. Results. It was found that 10 mi­nutes after taking mineral water, the gallbladder contraction was (19.36 ± 2.47) %, and after 50 minutes — (45.36 ± 3.02) %. After the course of therapy, all patients had bile homogenization and the disappearance of sludge. Biochemical indicators showed an increase in magnesium levels from (0.77 ± 0.04) to (0.87 ± 0.03) mmol/l, p = 0.017, a decrease in copper concentration from (19.80 ± 0.85) to (17.59 ± 0.68) μmol/l, p = 0.004, and a decrease in malondialdehyde levels from (6.63 ± 0.60) to (4.18 ± 0.30) μmol/l, p = 0.018. Correlation ana­lysis revealed a significant decrease in the Ca/Mg (p = 0.039) and MDA/Mg ratio (p = 0.018), reflecting an increase in antioxidant potential. Conclusions. Aqua Myrgorod Detox mine­ral water has a pronounced cholekinetic effect, helps normalize bile echostructure, improves magnesium balance and reduces the severity of oxidative stress. A comprehensive analysis of biochemical indicators confirms the feasibility of its use as a non-drug approach in the treatment of patients with biliary dysfunction.