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February 13, 2003Science

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

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Authors

SHShohei HoriThe University of TokyoTNTakashi NomuraKyoto University
Shimon Sakaguchi
Shimon SakaguchiScripps Research Institute

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Overview

Gene transfer of foxp3 alters t cell development in models of autoimmune disease, suggesting its vital role.

Key Points

  • Foxp3 is essential for the development of regulatory T cells, which maintain self-tolerance in the immune system.
  • Retroviral gene transfer of foxp3 transforms naïve T cells into a regulatory phenotype similar to natural CD4+ T cells.
  • The study identifies foxp3 as a critical transcription factor impacted in autoimmune and inflammatory conditions.
  • Understanding foxp3's role may lead to new strategies for the treatment of autoimmune syndromes linked to T cell dysfunction.

Cite This Study

Hori et al. (2003) studied this question.

synapsesocial.com/papers/68f648ee33dca03d982ea4a2https://doi.org/10.1126/science.1079490
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  1. 1Expression of the integrin α E β 7 identifies unique subsets of CD25 + as well as CD25 − regulatory T cells2002 · 457 citations
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  3. 3CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations2000 · 314 citations