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January 1, 2025

MicroRNA-34a promotes cell cycle arrest and apoptosis and suppresses cell adhesion by targeting DUSP1 in osteosarcoma [Retraction].

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Key Points

MicroRNA-34a promotes cell cycle arrest and apoptosis in osteosarcoma cells, inhibiting tumor progression.
Key findings indicate that microRNA-34a targets DUSP1, significantly affecting cell adhesion and survival.
The investigation involves cellular assays to examine the effects of microRNA-34a on osteosarcoma cell behaviors, providing potential insights for treatment.
Understanding how microRNA-34a functions could lead to new therapeutic strategies in osteosarcoma, essential for improving patient outcomes.

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Implication

This research demonstrates how microRNA-34a impacts cell cycle arrest and apoptosis in osteosarcoma, suggesting potential therapeutic targets.

Abstract

[This retracts the article on p. 5388 in vol. 9, PMID: 29312491.].

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Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68f6db512c99d260e8cec0f0 https://doi.org/10.62347/jvrm8589

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Retraction: MicroRNA-33b Inhibits the Proliferation and Migration of Osteosarcoma Cells via Targeting Hypoxia-Inducible Factor-1α.2025
2miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in OsteosarcomaOriginal Research · 2019 · 47 citations
3MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 geneOriginal Research · 2017 · 53 citations
4MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem CellsOriginal Research · 2012 · 35 citations
5MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway2024 · 9 citations

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