Review reveals mechanisms terminating responses to foreign antigens in lymphocytes, highlighting pathways that preserve self-tolerance and basal homeostasis.
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
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Parijs et al. (1998) studied this question.
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