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This research aims to understand how T cells develop tolerance to harmless antigens and the mechanisms involved.

Sequential plastic and terminal tolerogenic states limit helper T cell responses towards ingested antigen 2309592

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This research aims to understand how T cells develop tolerance to harmless antigens and the mechanisms involved.
Leveraged a mouse model of oral tolerization by transferring naive Ovalbumin-responsive T cells, which were then analyzed after antigen ingestion.
Used high-content, single-cell resolution analyses and genetic manipulation to track and understand donor T cell behavior.
Assessed transcriptional changes associated with anergy and pTreg development.
Identified a two-stage model of T cell tolerance: a proto-anergic state (Stage 1) followed by terminal states (Stage 2).
Stage 1 involves PD1 and BCL6, while Stage 2 is characterized by IL-2Ra and STAT5 signaling.
Both BCL6 and STAT5 are essential for sustaining T cell tolerance.

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Randomized trial investigates T cell tolerance dynamics in mice, indicating key regulatory mechanisms.

Villarino et al. (2026) studied this question.

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