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The study aims to clarify molecular mechanisms underlying T cell anergy and regulatory T cell development.

November 25, 2025The Journal of ImmunologyOpen Access

Stepwise progression from tolerogenic precursors to anergic and regulatory CD4 T cells 2838

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The study aims to clarify molecular mechanisms underlying T cell anergy and regulatory T cell development.
Utilized a mouse model of oral tolerance to analyze CD4 T cell responses.
Investigated the impact of PD-1 deficiency on T cell tolerance and differentiation.
Assessed the role of IL-2Ra and STAT5 signaling in the induction of pTreg.
First stage involves T cells entering a multipotent proto-anergic state with PD-1 induction.
Transition to terminal states (anergic or pTreg) is driven by inhibitory receptors and IL-2-STAT5 signaling.
PD-1 deficiency leads to loss of tolerance and promotes effector differentiation instead of pTreg development.

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Mouse model demonstrates roles of regulatory T cells and oral tolerance in T cell anergy progression.

Ristin et al. (2025) studied this question.

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