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This research aims to determine how different factors of dietary antigens influence the fate of CD4 T cells during the development of oral tolerance.

Dietary antigens gradually inactivate CD4+ T cells to produce oral tolerance 2258629

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This research aims to determine how different factors of dietary antigens influence the fate of CD4 T cells during the development of oral tolerance.
Adoptively transferred naïve OTII CD4 T cells into mice and administered varying doses of ovalbumin (OVA).
Conducted fate mapping analyses and utilized antigen-specific tetramers to assess CD4 T cell populations.
Performed single-cell RNA sequencing to explore transcriptomic changes in activated CD4 T cells.
Repetitive administration of OVA increased expression of anergy-associated markers like Ctla-4 and Nrp-1, indicating enhanced CD4 T cell inactivation (p<0.05).
Majority of OTII CD4 T cells became apoptotic after multiple OVA exposures, with regulatory and anergic programs being primarily exclusive.
Tolerance effects were transient, dissipating swiftly after OVA discontinuation.

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Randomized trial analyzes antigen exposure effects on oral tolerance in mice, suggesting gradual CD4 T cell inactivation.

Albarrán‐Godínez et al. (2026) studied this question.

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