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October 22, 2025

Clinical efficacy of osmotic release oral system methylphenidate combined with electroencephalographic biofeedback and sensory integration training in children with attention deficit hyperactivity disorder.

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Authors

YZYue ZhaoHarbin Medical UniversityCDChenguang DuNorthwest Normal UniversityHLHe LiAnyang Eye Hospital

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Overview

Retrospective study finds OROS-MPH combined with EEG biofeedback improves ADHD symptoms and cognitive function, implying significant benefits of multimodal therapy.

Key Points

  • Multimodal therapy combining OROS-MPH and EEG biofeedback significantly improves behavioral symptoms in ADHD children compared to medication alone.
  • The observation group had a notable reduction in SNAP-IV and CPRS-48 scores, showing enhanced improvement in cognitive function.
  • Physiological outcomes demonstrated increased cerebral blood flow velocities and marked changes in neuroendocrine markers across both groups.
  • No serious adverse effects were reported, highlighting the safety of this combined therapeutic approach.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68f83307d24b29c9694813bbhttps://doi.org/10.62347/owzf9195
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osmotic-Release Oral System Methylphenidate Augmentation of Antidepressant Monotherapy in Major Depressive Disorder2008 · 119 citations
  2. 2Effectiveness of Methylphenidate Plus Integrated Training in Children with Comorbid SLD and ADHD: A Retrospective Pre–Post Intervention Study2025
  3. 3Analysis of the therapeutic effect of pestle needle & EEG biofeedback and methylphenidate in the treatment of attention deficit and hyperactivity disorder2024
  4. 4Norepinephrine transporter −3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment2011 · 20 citations
  5. 5Biofeedback for Attention Deficit and Hyperactivity Disorder in children: A pilot study of a multimodal approach of respiratory biofeedback to improve functional impact2026